Birth Defects Research Part A: Clinical and Molecular Teratology 2008-09-01

Carbimazole embryopathy-bilateral choanal atresia and patent vitello-intestinal duct: a case report and review of literature.

Lakshminarayanan Kannan, Satish Mishra, Ramesh Agarwal, Venkat Kartikeyan, Neerja Gupta, Madhulika Kabra

Index: Birth Defects Res. A Clin. Mol. Teratol. 82(9) , 649-51, (2008)

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Abstract

In utero exposure to carbimazole for maternal hyperthyroidism has been reported to cause choanal atresia. There are case reports of patent vitello-intestinal duct and Meckel's diverticulum in similar association.We report another such instance of an infant who was exposed to carbimazole in utero, presenting with bilateral choanal atresia and patent vitello-intestinal duct.As there seems to be no reports of a possible association between propylthiouracil and congenital malformations, it may be safer to use propylthiouracil instead of carbimazole.(c) 2008 Wiley-Liss, Inc.