Carbimazole

Modify Date: 2024-01-04 10:19:24

Carbimazole structure	Common Name	Carbimazole
	CAS Number	22232-54-8	Molecular Weight	186.232
	Density	1.3±0.1 g/cm3	Boiling Point	240.4±23.0 °C at 760 mmHg
	Molecular Formula	C₇H₁₀N₂O₂S	Melting Point	124°C
	MSDS	Chinese USA	Flash Point	99.2±22.6 °C

Use of Carbimazole

Carbimazole is an imidazole antithyroid agent. Target: OthersCarbimazole is an effective thyroid hormone inhibitor under a class of drugs known as pro-drugs. It is considered a pro-drug because it converts to methimazole after being absorbed by the body, generating an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland) [1]. Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine) [2].Carbimazole (CBZ) is one of the major drugs currently used for the treatment of Graves' disease. Experiments with [35S] CBZ in rats showed that the drug is so rapidly transformed to MMI after i.v. injection (within 3 min) that very little of the unchanged drug would be expected to reach the thyroid gland. The antithyroid action of CBZ in rats, therefore, can be ascribed entirely to the MMI to which it is rapidly converted [3].

Name	carbimazole
Synonym	More Synonyms

Description	Carbimazole is an imidazole antithyroid agent. Target: OthersCarbimazole is an effective thyroid hormone inhibitor under a class of drugs known as pro-drugs. It is considered a pro-drug because it converts to methimazole after being absorbed by the body, generating an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland) [1]. Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine) [2].Carbimazole (CBZ) is one of the major drugs currently used for the treatment of Graves' disease. Experiments with [35S] CBZ in rats showed that the drug is so rapidly transformed to MMI after i.v. injection (within 3 min) that very little of the unchanged drug would be expected to reach the thyroid gland. The antithyroid action of CBZ in rats, therefore, can be ascribed entirely to the MMI to which it is rapidly converted [3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Endocrinology
References	[1]. Taurog, A., The mechanism of action of the thioureylene antithyroid drugs. Endocrinology, 1976. 98(4): p. 1031-46. [2]. Magnusson, R.P., A. Taurog, and M.L. Dorris, Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. J Biol Chem, 1984. 259(1): p. 197-205. [3]. Nakashima, T. and A. Taurog, Rapid conversion of carbimazole to methimazole in serum; evidence for an enzymatic mechanism. Clin Endocrinol (Oxf), 1979. 10(6): p. 637-48.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Endocrinology

References

[1]. Taurog, A., The mechanism of action of the thioureylene antithyroid drugs. Endocrinology, 1976. 98(4): p. 1031-46.

[2]. Magnusson, R.P., A. Taurog, and M.L. Dorris, Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. J Biol Chem, 1984. 259(1): p. 197-205.

[3]. Nakashima, T. and A. Taurog, Rapid conversion of carbimazole to methimazole in serum; evidence for an enzymatic mechanism. Clin Endocrinol (Oxf), 1979. 10(6): p. 637-48.

Density	1.3±0.1 g/cm3
Boiling Point	240.4±23.0 °C at 760 mmHg
Melting Point	124°C
Molecular Formula	C₇H₁₀N₂O₂S
Molecular Weight	186.232
Flash Point	99.2±22.6 °C
Exact Mass	186.046295
PSA	68.25000
LogP	0.34
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.612
Storage condition	Refrigerator

Carbimazole MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ2441000

CHEMICAL NAME :: 4-Imidazoline-1-carboxylic acid, 3-methyl-2-thioxo-, ethyl ester

CAS REGISTRY NUMBER :: 22232-54-8

BEILSTEIN REFERENCE NO. :: 0144339

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C7-H10-N2-O2-S

MOLECULAR WEIGHT :: 186.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 703 mg/kg/17W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - change in acuity Sense Organs and Special Senses (Ear) - tinnitus

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 25 mg/kg/6W-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 23 mg/kg/5W-I

TOXIC EFFECTS :: Liver - jaundice, cholestatic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1 mg/kg/1D-I

TOXIC EFFECTS :: Liver - jaundice, other or unclassified

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 1 gm/L

REFERENCE :: CHINAG Chemistry and Industry (London). (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK) V.1- 1923- Volume(issue)/page/year: (21),847,1980

Risk Phrases	R22
Safety Phrases	S22-S36/37/39
RIDADR	3335
RTECS	NJ2441000
HS Code	2922499915

methylimidazole

CAS#:616-47-7

Ethyl chloroformate

CAS#:541-41-3

~87%

Carbimazole

CAS#:22232-54-8

Literature: Das, Debasis; Roy, Gouriprasanna; Mugesh, Govindasamy Journal of Medicinal Chemistry, 2008 , vol. 51, # 22 p. 7313 - 7317

Methimazole

CAS#:60-56-0

Ethyl chloroformate

CAS#:541-41-3

Carbimazole

CAS#:22232-54-8

Literature: Journal of the Chemical Society, , p. 1103,1106 US2671088 , ; US2815349 , ;

Carbonothioic a...

CAS#:497-98-3

Carbimazole

CAS#:22232-54-8

Literature: Journal of the Chemical Society, , p. 2387,2390

Pyridine

CAS#:110-86-1

Methimazole

CAS#:60-56-0

Ethyl chloroformate

CAS#:541-41-3

Carbimazole

CAS#:22232-54-8

Literature: Journal of the Chemical Society, , p. 1103,1106 US2671088 , ; US2815349 , ;

Carbonothioic a...

CAS#:497-98-3

Diethyl ether

CAS#:60-29-7

Pyridine chlorh...

CAS#:628-13-7

Carbimazole

CAS#:22232-54-8

Literature: Journal of the Chemical Society, , p. 2387,2390

Carbonothioic a...

CAS#:497-98-3

Diethyl ether

CAS#:60-29-7

Ethyl chloroformate

CAS#:541-41-3

Carbimazole

CAS#:22232-54-8

Literature: Journal of the Chemical Society, , p. 2387,2390

Precursor 7
CAS#:616-47-7 methylimidazole CAS#:541-41-3 Ethyl chloroformate CAS#:60-56-0 Methimazole CAS#:497-98-3 Carbonothioic a...
CAS#:110-86-1 Pyridine CAS#:60-29-7 Diethyl ether CAS#:628-13-7 Pyridine chlorh...
DownStream 2
CAS#:61640-28-6 1-ethyl-3-methy... CAS#:50968-13-3 2-ethylsulfanyl...

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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To determine the pharmacokinetics of a novel lipophilic formulation of transdermal methimazole compared to oral carbimazole.Healthy cats received 5 mg carbimazole orally every 12 hours for 13 treatmen...

Carbimazolum

Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate

EINECS 244-854-4

Carbimazol

Carbimazole

Neo-Thyreostat

3-Methyl-2-thioxo-2,3-dihydro-imidazol-1-carbonsaeure-aethylester

1-Methyl-3-carbethoxy-2-thioglyoxalone

1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester

CG 1

Thyrostat

ethyl 3-methyl-2-thionoimidazoline-1-carboxylate

Carbethoxymethimazole

3-methyl-2-thioxo-2,3-dihydro-imidazole-1-carboxylic acid ethyl ester

ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate

3-methyl-1-ethoxycarbonylimidazoline-2-thione

Carbinazole

2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylic Acid Ethyl Ester

Athyromazole

1-Ethoxycarbonyl-3-methyl-2-thioxo-4-imidazoline

MFCD00027421

Neomercazole

1-Ethoxycarbonyl-3-methyl-2-thio-4-imidazoline

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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Carbimazole
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: carbimazole
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Purity: 99.0%
Stocking Period: Inquiry
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Carbimazole

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