Simple Preparation of Methyl 4-Chloromethyl-and Methyl 5-Chloromethyl-2-thiophenecarboxylate

V Kozmík, J Paleček

Index: Kozmik, Vaclav; Palecek, Jaroslav Collection of Czechoslovak Chemical Communications, 1992 , vol. 57, # 7 p. 1483 - 1486

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Citation Number: 3

Abstract

Abstract Selective reduction of a mixture of methyl 4-chloromethyl-2-thiophenecarboxylate (I) and the 5-chloromethyl isomer II, prepared by chloromethylation of methyl 2- thiophenecarboxylate (III), gave pure 4-chloromethyl derivative I and 5-methyl-2- thiophenecarboxylate (V) which on treatment with sulfuryl chloride was converted into the 5- chloromethyl isomer II.