Journal of Pharmaceutical and Biomedical Analysis 1993-01-01

Cholanic acids determined in commercial drugs by means of a new ISFET device.

L Campanella, M Battilotti, A Borraccino, C Colapicchioni, M P Sammartino, M Tomassetti

Index: J. Pharm. Biomed. Anal. 11(11-12) , 1207-14, (1993)

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Abstract

An ISFET device selective for cholanic acids, based on a PVC-sebacate membrane, containing benzyldimethylcetylammoniumcholate as exchanger, has been prepared, characterized and applied to the determination of cheno or ursodeoxycholic acid content of commercial pharmaceutical drugs and critical micellar concentration (CMC) values for cholate, deoxycholate and chenodeoxycholate. The results are compared with those obtained using previously described polymeric membrane sensors based on the same exchanger.