European Journal of Pharmacology 1983-08-19

Antagonism of the discriminative effects of diazepam by pyrazoloquinolines in rats.

H E Shannon, S Herling

Index: Eur. J. Pharmacol. 92(1-2) , 155-7, (1983)

Full Text: HTML

Abstract

The diazepam-like agonist and diazepam antagonist properties of the pyrazoloquinoline benzodiazepine receptor ligands CGS8216, CGS9895 and CGS9896 were evaluated in rats trained to discriminate between saline and 1.0 mg/kg of diazepam in a two-choice, discrete-trial procedure. None of the three pyrazoloquinolines produced diazepam-like discriminative effects over the dose range of 1.0-30 mg/kg. The effects of 1.0 mg/kg of diazepam were antagonized by CGS8216 and CGS9895, but not by CGS9896. The present results provide behavioral evidence for benzodiazepine receptor heterogeneity.