Neuron 2007-04-19

Switching gears: translational mastery of transcription during memory formation.

Charles A Hoeffer, Eric Klann

Index: Neuron 54(2) , 186-9, (2007)

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Abstract

A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a key regulatory event in the "neural decision" to undergo these persistent neuronal changes under translational control mediated by eIF2alpha.