B12 mimicry in a weak ligand environment: oxidation and alkylation of thiols

S Chowdhury, PM Samuel, I Das, S Roy

Index: Chowdhury, Shantanu; Samuel, Purnima M.; Das, Indira; Roy, Sujit Journal of the Chemical Society, Chemical Communications, 1994 , # 17 p. 1993 - 1994

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Citation Number: 3

Abstract

The first examples of alkylation and oxidation of thiols by cobalt in weakly coordinating ligand (MeCN) environment is presented as a mimic to B12-dependent nonentymatic reaction. ... Over three decades ago it was demonstrated that (a) vitamin BI2 (Factor B) and aquocobalamin mediate the oxidation of thiols in sulfur containing amino acids at pH b 61 and (6) aquocobalamin can be methylated2 by MeI-RSH while thiolate ions can be alkylated3 by alkylcobalamin at ...