Journal of Asian Natural Products Research 2011-03-01

Two new compounds from an endophytic fungus Aspergillus sp. HS-05.

Lin Zhang, Gang Chen, Hong-Hua Wu, Xuan Lu, Yue-Hu Pei, Xin Wu, Bo Pan, Hui-Ming Hua, Jiao Bai

Index: J. Asian Nat. Prod. Res. 13(3) , 225-9, (2011)

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Abstract

Two new compounds, N-[4'-hydroxy-(E)-cinnamoyl]-l-tyrosine methyl ester (1) and methyl 4-methoxy-3-(3'-hydroxy-2'-methyl)propionyloxy-benzoate (2), were isolated from EtOAc extract of the fermentation broth of the endophytic fungus Aspergillus sp. HS-05. Their structures were elucidated by NMR, IR, UV, MS, and CD methods. Compounds 1 and 2 showed no anticancer activities against HL-60 cell lines (both of IC(50)>100 μM) in vitro.