Journal of Fluorine Chemistry

The synthesis of antiinflammatory α-(trifluoromethyl) arylacetic acids

WJ Middleton, EM Bingham

Index: Middleton, W. J.; Bingham, E. M. Journal of Fluorine Chemistry, 1983 , vol. 22, p. 561 - 574

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Citation Number: 21

Abstract

Abstract Several novel α-trifluoromethylarylacetic acids were synthesized, utilizing chloropentafluoroacetone as the source of the trifluoromethyl group. One of these new acids, the trifluoro-analog (30) of ibuprofen, showed antiinflammatory, analgesic, and ulcerogenic properties similar to ibuprofen.