An efficient method for the N-arylation of phenylurea via copper catalyzed amidation

…, MS Mane, PN Pabrekar, MS Shingare, DV Mane

Index: Gavade, Sandip N.; Balaskar, Ravi S.; Mane, Madhav S.; Pabrekar, Pramod N.; Shingare, Murlidhar S.; Mane, Dhananjay V. Chinese Chemical Letters, 2011 , vol. 22, # 6 p. 675 - 678

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Citation Number: 6

Abstract

Abstract The coupling reaction of phenylurea with different functionalized aryl halides in the presence of air stable CuI, N, N-dimethylethylenediamine as a ligand, and K 3 PO 4 as a base gives symmetrical and unsymmetrical diarylureas in relatively high yields. This method is milder than the palladium catalyzed arylation and avoids the use of toxic phosphine ligands.