Applied and Environmental Microbiology 1998-08-01

Fungal biotransformation of 6-nitrochrysene.

J V Pothuluri, J B Sutherland, J P Freeman, C E Cerniglia

Index: Appl. Environ. Microbiol. 64(8) , 3106-9, (1998)

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Abstract

The fungus Cunninghamella elegans was used to biotransform 6-nitrochrysene, a mutagen that is a widespread environmental contaminant. After 6 days, 74% of the 3H-labeled 6-nitrochrysene added had been metabolized to two isomeric sulfate conjugates. These conjugates were separated by high-performance liquid chromatography and identified by UV-visible, 1H nuclear magnetic resonance, and mass spectral techniques as 6-nitrochrysene 1-sulfate and 6-nitrochrysene 2-sulfate.