Journal of Allergy and Clinical Immunology 1982-04-01

Chronic sinusitis in children with respiratory allergy: the role of antimicrobials.

G S Rachelefsky, R M Katz, S C Siegel

Index: J. Allergy Clin. Immunol. 69(4) , 382-7, (1982)

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Abstract

We evaluated the role of antimicrobials in the treatment of chronic maxillary sinusitis in children with respiratory allergy. Night and day cough, nasal obstruction, rhinorrhea, postnasal seen. Eighty-four children were treated in a double-blind manner with either amoxicillin, erythromycin, trimethoprim-sulfamethoxazole, or an antihistamine decongestant (carbinoxamine maleate-pseudoephedrine HCl). Radiographic and clinical responses were best with amoxicillin, but trimethoprim-sulfamethoxazole was an adequate alternative. This study demonstrates that allergic children with chronic sinusitis with associated chronic respiratory symptoms are likely to respond clinically and radiologically with antimicrobial treatment.