Organic Letters 2003-07-01

Generation of aza-ortho-xylylenes via ring opening of 2-(2-acylaminophenyl)aziridines: application in the construction of the communesin ring system.

M Todd Washington, Sandra A Helquist, Eric T Kool, Louise Prakash, Satya Prakash

Index: Org. Lett. 8 , 3995, (2006)

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Abstract

A new protocol for generating aza-ortho-xylylenes via acid-catalyzed or fluoride-promoted ring opening of 2-(2-acylaminophenyl)aziridines is described. This methodology has been exploited in the rapid construction of a hexacyclic substructure of communesin B.