Design and synthesis of l-and d-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase

…, D Dana, S Kumar, N Kaushik-Basu, TT Talele

Index: Patel, Bhargav A.; Krishnan, Ramalingam; Khadtare, Nikhil; Gurukumar; Basu, Amartya; Arora, Payal; Bhatt, Aaditya; Patel, Maulik R.; Dana, Dibyendu; Kumar, Sanjai; Kaushik-Basu, Neerja; Talele, Tanaji T. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 11 p. 3262 - 3271

Full Text: HTML

Citation Number: 8

Abstract

Hepatitis C virus (HCV) NS5B polymerase is a key target for anti-HCV therapeutics development. Herein, we report the synthesis and in vitro evaluation of anti-NS5B polymerase activity of a molecular hybrid of our previously reported lead compounds 1 (IC50= 7.7 μM) and 2 (IC50= 10.6 μM) as represented by hybrid compound 27 (IC50= 6.7 μM). We have explored the optimal substituents on the terminal phenyl ring of the 3- ...