Toxicological European research. Recherche europeenne en toxicologie 1981-11-01

[Hepatic microsomal monoxygenase inhibition by nabam in the rat (author's transl)].

A Périquet, R Derache

Index: Toxicol. Eur. Res. 3(6) , 285-91, (1981)

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Abstract

Nabam (fungicide dithiocarbamate) has been incorporated with the diet of rats during six months (the doses were: 0, 10, 50, 100, 500, 1000 and 2000 ppm). It decreases significantly the hepatic microsomal enzymes activity (aniline hydroxylase and aminopyrine N-demethylase and the liver P 450 content, but the cytochrome b 5 concentration doesn't seem to be modified. The microsomal lipidic and proteic content is only modified with the highest Nabam dose. Several hypotheses may be proposed to explain the Nabam effects: one is the inhibition of the monooxygenases and their biosynthesis repression.