The Journal of Organic Chemistry

An efficient synthesis of 2-(halogenomethyl) penems

M Altamura, E Perrotta

Index: Altamura, Maria; Perrotta, Enzo Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 272 - 274

Full Text: HTML

Citation Number: 18

Abstract

The penems 1 (Scheme I) are highly potent broadspectrum 8-lactam antibiotics structurally related to the naturally occurring penicillins, cephalosporins, and carbapenems.'While the substituent at C-6 is usually chosen to be 1 (R)-hydroxyethyl (l), also characteristic of the naturally occurring carbapenem thienamycin? or its close analog hydroxymethyl (2), a large differentiation is possible in the nature of the X substituent at C-2.1 b Following the interest ...