kojic acid

Modify Date: 2024-01-01 22:32:29

kojic acid structure	Common Name	kojic acid
	CAS Number	501-30-4	Molecular Weight	142.11
	Density	1.5±0.1 g/cm3	Boiling Point	401.7±45.0 °C at 760 mmHg
	Molecular Formula	C₆H₆O₄	Melting Point	152-155 °C(lit.)
	MSDS	Chinese USA	Flash Point	179.9±22.2 °C

Use of kojic acid

Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent[1].

Name	kojic acid
Synonym	More Synonyms

Description	Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. Wei X, et al. Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways. Exp Eye Res. 2018 Dec 28;180:174-183.

Density	1.5±0.1 g/cm3
Boiling Point	401.7±45.0 °C at 760 mmHg
Melting Point	152-155 °C(lit.)
Molecular Formula	C₆H₆O₄
Molecular Weight	142.11
Flash Point	179.9±22.2 °C
Exact Mass	142.026611
PSA	70.67000
LogP	-0.64
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.607
Storage condition	Refrigerator
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	SOLUBLE

kojic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0875000

CHEMICAL NAME :: 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-

CAS REGISTRY NUMBER :: 501-30-4

BEILSTEIN REFERENCE NO. :: 0120895

LAST UPDATED :: 199612

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C6-H6-O4

MOLECULAR WEIGHT :: 142.12

WISWESSER LINE NOTATION :: T6O DVJ B1Q EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 4500 mg/L

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 59,213,1991

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	R40
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UQ0875000
HS Code	29329995

Precursor 10
CAS#:7559-81-1 4H-Pyran-4-one,... CAS#:67-64-1 Acetone CAS#:58-86-6 D-(+)-Xylose CAS#:5328-37-0 L-(+)-Arabinose
CAS#:26209-93-8 4H-Pyran-4-one,... CAS#:50-99-7 D-(+)-Glucose CAS#:56-81-5 Glycerol CAS#:50-70-4 Sorbitol
CAS#:608-66-2 Dulcitol CAS#:87-89-8 Inositol
DownStream 10
CAS#:496-63-9 Pyromeconic acid CAS#:31883-16-6 5-hydroxy-2-(hy... CAS#:1429-25-0 4H-Pyran-4-one,... CAS#:443955-90-6 2,3-dihydro[1,4...
CAS#:443955-89-3 (2,3-DIHYDRO-[1... CAS#:216581-47-4 6-methyl-4-oxo-... CAS#:2029-49-4 3-HYDROXY-2,6-B... CAS#:644-46-2 4H-Pyran-4-one,...
CAS#:6323-21-3 2-(hydroxymethy... CAS#:6269-25-6 2-(Hydroxymethy...

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Ciprofloxacin containing Mannich base and its copper complex induce antitumor activity via different mechanism of action.

Int. J. Oncol. 45(5) , 2092-100, (2014)

The Mannich base containing ciprofloxacin and kojic acid structural units was prepared and evaluated in antitumor activity. The enhancement in antitumor activity was observed both from the Mannich bas...

Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles.

Drug Des. Devel. Ther. 9 , 4259-68, (2015)

Tyrosinase is the most prominent target for inhibitors of hyperpigmentation because it plays a critical role in melaninogenesis. Although many tyrosinase inhibitors have been identified, from both nat...

Chemical compositions and biological activities of the essential oils of Beilschmiedia madang Blume (Lauraceae).

Arch. Pharm. Res. 38(4) , 485-93, (2015)

The present study aimed to examine the chemical compositions of the essential oils of Beilschmiedia madang and their antioxidant, antibacterial, antifungal, anticholinesterase and anti-tyrosinase acti...

2-(hydroxymethyl)-5-hydroxy-4H-pyran-4-one

5-hydroxy-2-(hydroxymethyl)pyran-4-one

UNII-6K23F1TT52

5-Hydroxy-2-(hydroxymethyl)-4-pyrone

5-Hydroxy-2-hydroxymethyl-4H-4-pyranone

2-Hydroxymethyl-5-hydroxy-γ-pyrone

MFCD00006580

5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

4H-PYRAN-4-ONE,5-HYDROXY-2-(HYDROXYMETHYL)

5-hydroxy-2-(hydroxmetyl)-4H-pyran-4-one

3-hydroxy-6-hydroxymethyl-4H-pyran-4-one

EINECS 207-922-4

BioBioPha
China
Product Name: kojic acid
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: kojic acid
Price: ￥128.0/100g ￥408.0/500g
Purity: 99.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Kojic acid
Price: $50.0/100mg $100.0/250mg $200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Kojic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Kojic acid
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Kojic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥40/10g

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kojic acid

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