Tetrahedron Letters

Greener and rapid access to bio-active heterocycles: one-pot solvent-free synthesis of 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles

V Polshettiwar, RS Varma

Index: Polshettiwar, Vivek; Varma, Rajender S. Tetrahedron Letters, 2008 , vol. 49, # 5 p. 879 - 883

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Citation Number: 110

Abstract

A novel one-pot solvent-free synthesis of 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles by condensation of acid hydrazide and triethyl orthoalkanates under microwave irradiations is reported. This green protocol was catalyzed efficiently by solid supported Nafion® NR50 and phosphorus pentasulfide in alumina (P4S10/Al2O3) with excellent yields.

~69%

~67%

~90%

~88%

~77%

~65%

~72%

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~70%

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