International Journal of Molecular Medicine 2004-08-01

Induction of apoptosis by ar-turmerone on various cell lines.

Mingjie Ji, Jaesue Choi, Jeongnyeo Lee, Yongkyu Lee

Index: Int. J. Mol. Med. 14(2) , 253-6, (2004)

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Abstract

This study investigated the cytotoxic effect of ar-turmerone isolated from turmeric (Curcuma longa L) on the K562, L1210, U937 and RBL-2H3 cell lines by the MTT assay. Ar-turmerone exhibited potent cytotoxicity on these cancer cell lines. The IC50 values of ar-turmerone on these cell lines were 20-50 microg/ml. They showed an increased inhibition ratio on cell viability according to the drug concentration < or = 80 microg/ml in the cell lines tested. The DNA fragmentation that is a characteristic of apoptosis due to ar-turmerone occurred in a concentration- and time-dependent manner in the K562, L1210, U937 and RBL-2H3 cancer cell lines. These results suggest that ar-turmerone can induce the apoptotic activity in the K562, L1210, U937 and RBL-2H3 cells.