Synlett

The palladium catalysed Suzuki coupling of 2-and 4-chloropyridines

O Lohse, P Thevenin, E Waldvogel

Index: Lohse, Olivier; Thevenin, Philippe; Waldvogel, Erwin Synlett, 1999 , # 1 p. 45 - 48

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Citation Number: 108

Abstract

Abstract: The Suzuki coupling of 2-and 4-chloropyridines with arylboronic acids is successfully performed under Pd (PPh3) 4 catalysis. Moderate to good yields are obtained with 4-chloropyridines while 2-chloropyridines give excellent yields. The corresponding pyridine N-oxides react in the same manner. An easy and cheap access to arylpyridines, a class of compound with medicinal interest, is thus achieved. Key words: chloropyridines, ...