A facile synthesis of 4-hydroxy-and 4-aminoindoles through corresponding indolines.

H Tanaka, Y Murakami, T Aizawa, S Torii

Index: Tanaka; Murakami; Aizawa; Torii Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 11 p. 3742 - 3744

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Citation Number: 10

Abstract

2-(2, 6-Diaminophenyl) ethanol can be conducted to 4-hydroxyindoline under heating in aqueous 70% phosphoric acid, and to 4-aminoindoline under heating in aqueous 30% sulfuric acid. Both 4-hydroxy-and 4-aminoindoles were obtained by dehydrogenation of the indolines under refluxing in 1, 4-dimethylbenzene over palladium on charcoal.