Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2013-09-01

Spectroscopic studies on the interaction of carteolol hydrochloride and urea-induced bovine serum albumin.

Qing Yao, Xianyong Yu, Tongyin Zheng, Heting Liu, Ying Yang, Pinggui Yi

Index: Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 113 , 447-51, (2013)

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Abstract

The interaction of carteolol hydrochloride, to 0.2 mol L(-1) urea-induced bovine serum albumin in aqueous solution has been first investigated by fluorescence spectra and ultraviolet-visible (UV-vis) spectra at pH 7.40. The quenching mechanism, binding parameter and sites (n), the binding mode (ΔG, ΔH, and ΔS) as well as the binding distance (r) have been obtained according to the experimental results. We also use the synchronous fluorescence method to study the effect of CTL on the conformation change of urea-induced BSA.Copyright © 2013 Elsevier B.V. All rights reserved.