Design, synthesis and anticancer activity evaluation of diazepinomicin derivatives

Y Yu, J Wu, F Lei, L Chen, W Wan, L Hai…

Index: Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373

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Citation Number: 4

Abstract

A series of diazepinomicin derivatives were synthesized and evaluated in vitro for their growth inhibitory activity against the human carcinoma cell lines. The results indicated the anticancer selectivity of this kind of compounds. Based on the results, preliminary structure- activity relationships were discussed.

 Related Synthetic Route
(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienoic acid ethyl ester Structure

19954-66-6

(2E,6E)-3,7,11-...

~92%

(2E,6E)-Farnesol Structure

106-28-5

(2E,6E)-Farnesol

Toluene Structure

108-88-3

Toluene

~70%

2-Nitrotoluene Structure

88-72-2

2-Nitrotoluene

2'-Nitroacetanilide Structure

552-32-9

2'-Nitroacetanilide

~%

2-(2-NITROPHENYLAMINO)BENZOIC ACID Structure

5933-35-7

2-(2-NITROPHENY...

Toluene Structure

108-88-3

Toluene

~%

2-(2-NITROPHENYLAMINO)BENZOIC ACID Structure

5933-35-7

2-(2-NITROPHENY...

2-Nitrotoluene Structure

88-72-2

2-Nitrotoluene

~%

2-(2-NITROPHENYLAMINO)BENZOIC ACID Structure

5933-35-7

2-(2-NITROPHENY...

2-Nitrobenzoic acid Structure

552-16-9

2-Nitrobenzoic acid

~%

2-(2-NITROPHENYLAMINO)BENZOIC ACID Structure

5933-35-7

2-(2-NITROPHENY...

Anthranilic acid Structure

118-92-3

Anthranilic acid

~%

2-(2-NITROPHENYLAMINO)BENZOIC ACID Structure

5933-35-7

2-(2-NITROPHENY...

Structure

74497-02-2

~%

2-(2-NITROPHENYLAMINO)BENZOIC ACID Structure

5933-35-7

2-(2-NITROPHENY...

Acetanilide Structure

103-84-4

Acetanilide

~%

2-(2-NITROPHENYLAMINO)BENZOIC ACID Structure

5933-35-7

2-(2-NITROPHENY...

Geranyl bromide Structure

6138-90-5

Geranyl bromide

~%

Geranylacetone Structure

3796-70-1

Geranylacetone

Geraniol Structure

106-24-1

Geraniol

~%

Geranylacetone Structure

3796-70-1

Geranylacetone

2'-Nitroacetanilide Structure

552-32-9

2'-Nitroacetanilide

~%

5,10-DIHYDRO-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE Structure

5814-41-5

5,10-DIHYDRO-DI...

Toluene Structure

108-88-3

Toluene

~%

5,10-DIHYDRO-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE Structure

5814-41-5

5,10-DIHYDRO-DI...

2-Nitrotoluene Structure

88-72-2

2-Nitrotoluene

~%

5,10-DIHYDRO-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE Structure

5814-41-5

5,10-DIHYDRO-DI...

2-Nitrobenzoic acid Structure

552-16-9

2-Nitrobenzoic acid

~%

5,10-DIHYDRO-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE Structure

5814-41-5

5,10-DIHYDRO-DI...

2-Iodobenzoic acid Structure

88-67-5

2-Iodobenzoic acid

~%

5,10-DIHYDRO-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE Structure

5814-41-5

5,10-DIHYDRO-DI...

Structure

74497-02-2

~%

5,10-DIHYDRO-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE Structure

5814-41-5

5,10-DIHYDRO-DI...

Acetanilide Structure

103-84-4

Acetanilide

~%

5,10-DIHYDRO-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE Structure

5814-41-5

5,10-DIHYDRO-DI...

2-Iodobenzoic acid Structure

88-67-5

2-Iodobenzoic acid

4-Chloro-2-nitroaniline Structure

89-63-4

4-Chloro-2-nitr...

~%

2-((4-CHLORO-2-NITROPHENYL)AMINO)BENZOIC ACID Structure

60091-87-4

2-((4-CHLORO-2-...

Toluene Structure

108-88-3

Toluene

~%

2-((4-CHLORO-2-NITROPHENYL)AMINO)BENZOIC ACID Structure

60091-87-4

2-((4-CHLORO-2-...

2-Nitrotoluene Structure

88-72-2

2-Nitrotoluene

~%

2-((4-CHLORO-2-NITROPHENYL)AMINO)BENZOIC ACID Structure

60091-87-4

2-((4-CHLORO-2-...

2-Nitrobenzoic acid Structure

552-16-9

2-Nitrobenzoic acid

~%

2-((4-CHLORO-2-NITROPHENYL)AMINO)BENZOIC ACID Structure

60091-87-4

2-((4-CHLORO-2-...

Anthranilic acid Structure

118-92-3

Anthranilic acid

~%

2-((4-CHLORO-2-NITROPHENYL)AMINO)BENZOIC ACID Structure

60091-87-4

2-((4-CHLORO-2-...

4-Chloroaniline Structure

106-47-8

4-Chloroaniline

~%

2-((4-CHLORO-2-NITROPHENYL)AMINO)BENZOIC ACID Structure

60091-87-4

2-((4-CHLORO-2-...

4-Chloroacetanilide Structure

539-03-7

4-Chloroacetanilide

~%

2-((4-CHLORO-2-NITROPHENYL)AMINO)BENZOIC ACID Structure

60091-87-4

2-((4-CHLORO-2-...

3-Methyl-2-nitroanisole Structure

5345-42-6

3-Methyl-2-nitr...

~65%

2-Nitro-3-methoxybenzoic acid Structure

4920-80-3

2-Nitro-3-metho...

WNR BQ F1 Structure

4920-77-8

WNR BQ F1

~%

2-Nitro-3-methoxybenzoic acid Structure

4920-80-3

2-Nitro-3-metho...

2-((4-CHLORO-2-NITROPHENYL)AMINO)BENZOIC ACID Structure

60091-87-4

2-((4-CHLORO-2-...

~%

8-Chloro-11-oxo-10,11-dihydro-5H-dibenzo-1,4-diazepine Structure

50892-62-1

8-Chloro-11-oxo...

N-(4-Chloro-2-nitrophenyl)acetamide Structure

881-51-6

N-(4-Chloro-2-n...

~%

8-Chloro-11-oxo-10,11-dihydro-5H-dibenzo-1,4-diazepine Structure

50892-62-1

8-Chloro-11-oxo...

4-Chloro-2-nitroaniline Structure

89-63-4

4-Chloro-2-nitr...

~%

8-Chloro-11-oxo-10,11-dihydro-5H-dibenzo-1,4-diazepine Structure

50892-62-1

8-Chloro-11-oxo...

Toluene Structure

108-88-3

Toluene

~%

8-Chloro-11-oxo-10,11-dihydro-5H-dibenzo-1,4-diazepine Structure

50892-62-1

8-Chloro-11-oxo...

2-Nitrotoluene Structure

88-72-2

2-Nitrotoluene

~%

8-Chloro-11-oxo-10,11-dihydro-5H-dibenzo-1,4-diazepine Structure

50892-62-1

8-Chloro-11-oxo...

2-Nitrobenzoic acid Structure

552-16-9

2-Nitrobenzoic acid

~%

8-Chloro-11-oxo-10,11-dihydro-5H-dibenzo-1,4-diazepine Structure

50892-62-1

8-Chloro-11-oxo...

2-Iodobenzoic acid Structure

88-67-5

2-Iodobenzoic acid

~%

8-Chloro-11-oxo-10,11-dihydro-5H-dibenzo-1,4-diazepine Structure

50892-62-1

8-Chloro-11-oxo...

4-Chloroaniline Structure

106-47-8

4-Chloroaniline

~%

8-Chloro-11-oxo-10,11-dihydro-5H-dibenzo-1,4-diazepine Structure

50892-62-1

8-Chloro-11-oxo...

4-Chloroacetanilide Structure

539-03-7

4-Chloroacetanilide

~%

8-Chloro-11-oxo-10,11-dihydro-5H-dibenzo-1,4-diazepine Structure

50892-62-1

8-Chloro-11-oxo...

N-(4-Chloro-2-nitrophenyl)acetamide Structure

881-51-6

N-(4-Chloro-2-n...

~%

2-((4-CHLORO-2-NITROPHENYL)AMINO)BENZOIC ACID Structure

60091-87-4

2-((4-CHLORO-2-...


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