Organic Letters 2012-08-17

Pd-catalyzed C-H fluorination with nucleophilic fluoride.

Kate B McMurtrey, Joy M Racowski, Melanie S Sanford

Index: Org. Lett. 14(16) , 4094-7, (2012)

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Abstract

The palladium-catalyzed C-H fluorination of 8-methylquinoline derivatives with nucleophilic fluoride is reported. This transformation involves the use of AgF as the fluoride source in combination with a hypervalent iodine oxidant. Both the scope and mechanism of the reaction are discussed.