Nonpeptide inhibitors of measles virus entry

…, A Prussia, W Zhan, EE Murray, J Doyle…

Index: Sun, Aiming; Prussia, Andrew; Zhan, Weiqiang; Murray, Ernest E.; Doyle, Joshua; Cheng, Li-Ting; Yoon, Jeong-Joong; Radchenko, Eugene V.; Palyulin, Vladimir A.; Compans, Richard W.; Liotta, Dennis C.; Plemper, Richard K.; Snyder, James P. Journal of Medicinal Chemistry, 2006 , vol. 49, # 17 p. 5080 - 5092

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Citation Number: 44

Abstract

Measles virus (MV) is one of the most infectious pathogens known. Despite the existence of a vaccine, over 500 000 deaths/year result from MV or associated complications. Anti- measles compounds could conceivably reverse these statistics. Previously, we described a homology model of the MV fusion protein trimer and a putative binding site near the head- neck region. The resulting model permitted the identification of two nonpeptidic entry ...