Bioorganic & Medicinal Chemistry Letters 2010-05-01

Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora.

Chavi Yenjai, Suchana Wanich, Chavi Yenjai, Suchana Wanich

Index: Bioorg. Med. Chem. Lett. 20 , 2821-3, (2010)

Full Text: HTML

Abstract

Flavones 1-4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a-4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, oximes 1c and 2c exhibited highly potent cytotoxicity against NCI-H187 cell line with IC(50) values of 0.014 and 0.23 microM, respectively. Oximes 4c and 5c showed strong cytotoxicity against NCI-H187 cell line with IC(50) values of 4.04 and 2.32 microM, respectively.2010 Elsevier Ltd. All rights reserved.