Tetrahedron

The tandem reaction combining radical and ionic processes: an efficient approach to substituted 3, 4-dihydroquinolin-2-ones

W Zhou, L Zhang, N Jiao

Index: Zhou, Wang; Zhang, Liangren; Jiao, Ning Tetrahedron, 2009 , vol. 65, # 10 p. 1982 - 1987

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Citation Number: 23

Abstract

3, 4-Dihydroquinolin-2-ones are of great importance in the areas of pharmaceuticals. However, the direct intramolecular radical cyclizations of the corresponding amide compounds favor 5-exo products 2. Reports on the radical cyclization reactions producing 3, 4-dihydroquinolin-2-one derivatives are limited. Herein, an efficient tandem reaction combining radical and ionic processes was developed, which provides a practical ...