Tetrahedron letters

A mild and selective method for the N-Boc deprotection by sodium carbonate

S El Kazzouli, J Koubachi, S Berteina-Raboin…

Index: El Kazzouli, Said; Koubachi, Jamal; Berteina-Raboin, Sabine; Mouaddib, Abderrahim; Guillaumet, Gerald Tetrahedron Letters, 2006 , vol. 47, # 48 p. 8575 - 8577

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Citation Number: 28

Abstract

A cleavage of N-tert-butyloxycarbonyl protection by Na2CO3 is reported. The N-free products are obtained in excellent yields. The compatibility of the method with the presence of acidic or basic groups is demonstrated. The reactions were performed on indole, azaindole, indazole, pyrazole, indolinone, quinolinone, and oxazolone.

~94%

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