Bioorganic & Medicinal Chemistry Letters 2005-12-01

Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.

Katrin Groebke Zbinden, Ulrike Obst-Sander, Kurt Hilpert, Holger Kühne, David W Banner, Hans-Joachim Böhm, Martin Stahl, Jean Ackermann, Leo Alig, Lutz Weber, Hans Peter Wessel, Markus A Riederer, Thomas B Tschopp, Thierry Lavé

Index: Bioorg. Med. Chem. Lett. 15(23) , 5344-52, (2005)

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Abstract

We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.