Neuroscience Letters 2014-10-17

The ErbB2 inhibitor Herceptin (Trastuzumab) promotes axonal outgrowth four weeks after acute nerve transection and repair

Eva Placheta, J. Michael Hendry, Matthew D. Wood, Christine W. Lafontaine, Edward H. Liu, M. Cecilia Alvarez Veronesi, Manfred Frey, Tessa Gordon, Gregory H. Borschel

Index: Neurosci. Lett. 582 , 81-6, (2014)

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Abstract

• Herceptin administration after nerve repair increases axonal outgrowth. • Neuregulin mediated ErbB2 activation does not change with Herceptin treatment. • Motor and sensory neuron regeneration is not altered by Herceptin treatment.