Synthesis 2012-02-01

One-pot Double Suzuki Couplings of Dichloropyrimidines.

SamanthaC Anderson, ScottT Handy

Index: Synthesis 2010(16) , 2721-2724, (2010)

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Abstract

An effective one-pot, regioselective double Suzuki coupling of 2,4-dichloropyrimidine has been developed, which enables the quick and efficient synthesis of diarylated pyrimidines. The choice of solvent proved critical to the success of this reaction sequence, with alcoholic solvent mixtures affording much greater reactivity and correspondingly lower temperatures than the use of polar aprotic solvents.