Bioorganic & Medicinal Chemistry Letters 2007-06-15

Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.

Mahbub Alam, Rebekah E Beevers, Tom Ceska, Richard J Davenport, Karen M Dickson, Mara Fortunato, Lewis Gowers, Alan F Haughan, Lynwen A James, Mark W Jones, Natasha Kinsella, Christopher Lowe, Johannes W G Meissner, Anne-Lise Nicolas, Benjamin G Perry, David J Phillips, William R Pitt, Adam Platt, Andrew J Ratcliffe, Andrew Sharpe, Laura J Tait

Index: Bioorg. Med. Chem. Lett. 17 , 3463, (2007)

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Abstract

The development of a series of novel aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a c-Jun cellular assay are discussed.