Journal of heterocyclic chemistry

Synthesis and antitumor activity of new thiosemicarbazones of 2??acetylimidazo [4, 5??b] pyridine

S Mylonas, A Mamalis

Index: Mylonas, Stavros; Mamalis, Athanasios Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 7 p. 1273 - 1281

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Citation Number: 19

Abstract

Abstract A number of thiosemicarbazones of 2-acetyl-imidazo [4, 5-b] pyridine were prepared in order to investigate their in vitro antineoplastic activities. Three compounds:(i) 2- acetylimidazo [4, 5-b] pyridin-4-sec-butyl-3-thiosemicarbazone [(A 7), NSC674098],(ii) 2- acetylimidazo [4, 5-b] pyridin-4-tert-butyl-3-thiosemi-carbazone [(A 9), NSC674099],(iii) 2- acetylimidazo [4, 5-b] pyridin-4-cyclohexyl-3-thiosemicarbozone [(A 11), NSC674101] ...