Bioorganicheskaia khimiia 1998-01-01

[Acyclic nucleotide analogues based on phosphonic acids].

E V Efimtseva, S N Mikhaĭlov, M V Fomicheva, S V Meshkov, M S Rodionov, A R Khomutov, E De Clercq

Index: Bioorg. Khim. 24(1) , 16-20, (1998)

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Abstract

The synthesis of novel nucleotide analogues on the basis of ethylphosphonic acid was described. A rigid structural element, an amide or a double bond, was characteristics of the compounds synthesized. The antiviral and cytotoxic activities of these compounds were studied in cell cultures.