e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Journal of heterocyclic chemistry

Voies d'accès aux bisaminopyrimidines pontées par une chaine polyméthylenique

G Menichi, M Hubert??Habart

Index: Menichi, Gabriel; Hubert-Habart, Michel Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 209 - 213

Full Text: HTML

Citation Number: 4

Abstract

Abstract Seules parmi les produits isomères possibles les N (2), N'(2′) α, ω alcanediylbis (amino-2 pyrimidines) sont formées lorsque des polyméthylènebisguanidines sont condensées avec l'éthoxyméthylènemalonate d'éthyle, la méthyl-3 chromone, la flavone, l'acétylacétaldéhyde diméthylacétal, et l'acétyl-3 éthyl-2 benzofuranne. Abstract N (2), N′(2′)-αω-Alkandiylbis (2-aminopyrimidines) are the sole products obtained by ...

2H-1-Benzopyran-2-one,3-methyl- Structure

2H-1-Benzopyran...

(+/-)-1-methyl-cyclohexane-1r,2t-dicarboxylic acid dimethyl ester Structure

(+/-)-1-methyl-...

~43%

Phenol,2,2'-[1,8-octanediylbis[imino(5-methyl-2,4-pyrimidinediyl)]]bis- (9CI) Structure

Phenol,2,2'-[1,...

1,8-Diaminooctane Structure

1,8-Diaminooctane

~%

Phenol,2,2'-[1,8-octanediylbis[imino(5-methyl-2,4-pyrimidinediyl)]]bis- (9CI) Structure

Phenol,2,2'-[1,...

1,8-Diaminooctane Structure

1,8-Diaminooctane

~%

Phenol,2,2'-[1,8-octanediylbis[imino(6-phenyl-2,4-pyrimidinediyl)]]bis- (9CI) Structure

Phenol,2,2'-[1,...

(+/-)-1-methyl-cyclohexane-1r,2t-dicarboxylic acid dimethyl ester Structure

(+/-)-1-methyl-...

Diethyl ethoxymethylenemalonate Structure

Diethyl ethoxym...

~40%

5-Pyrimidinecarboxylicacid, 2,2'-(1,8-octanediyldiimino)bis[1,4-dihydro-4-oxo-, diethyl ester (9CI) Structure

5-Pyrimidinecar...

1,8-Diaminooctane Structure

1,8-Diaminooctane

~%

5-Pyrimidinecarboxylicacid, 2,2'-(1,8-octanediyldiimino)bis[1,4-dihydro-4-oxo-, diethyl ester (9CI) Structure

5-Pyrimidinecar...

(+/-)-1-methyl-cyclohexane-1r,2t-dicarboxylic acid dimethyl ester Structure

(+/-)-1-methyl-...

2,4-Pentandione Structure

2,4-Pentandione

~81%

N,N-bis(4,6-dimethylpyrimidin-2-yl)octane-1,8-diamine Structure

N,N-bis(4,6-dim...

1,8-Diaminooctane Structure

1,8-Diaminooctane

~%

N,N-bis(4,6-dimethylpyrimidin-2-yl)octane-1,8-diamine Structure

N,N-bis(4,6-dim...

bromhydrate de hexanediylbisguanidine Structure

bromhydrate de ...

2,4-Pentandione Structure

2,4-Pentandione

~62%

N,N-bis(4,6-dimethylpyrimidin-2-yl)hexane-1,6-diamine Structure

N,N-bis(4,6-dim...

1,6-Hexanediamine Structure

1,6-Hexanediamine

~%

N,N-bis(4,6-dimethylpyrimidin-2-yl)hexane-1,6-diamine Structure

N,N-bis(4,6-dim...

4,4-Dimethoxy-2-butanone Structure

4,4-Dimethoxy-2...

bromhydrate de propanediylbisguanidine Structure

bromhydrate de ...

~52%

N,N-bis(4-methylpyrimidin-2-yl)propane-1,3-diamine Structure

N,N-bis(4-methy...

4,4-Dimethoxy-2-butanone Structure

4,4-Dimethoxy-2...

bromhydrate de propanediylbisguanidine Structure

bromhydrate de ...

~45%

N,N-bis(4-methylpyrimidin-2-yl)propane-1,3-diamine Structure

N,N-bis(4-methy...

N/A Structure

1,6-Hexanediamine Structure

1,6-Hexanediamine

~%

(6E)-6-[2-[6-[[(4E)-4-(6-oxo-1-cyclohexa-2,4-dienylidene)-6-phenyl-3H-pyrimidin-2-yl]amino]hexylamino]-6-phenyl-3H-pyrimidin-4-ylidene]cyclohexa-2,4-dien-1-one Structure

(6E)-6-[2-[6-[[...

bromhydrate de butanediylbisguanidine Structure

bromhydrate de ...

Diethyl ethoxymethylenemalonate Structure

Diethyl ethoxym...

~15%

ethyl 2-[4-[(5-ethoxycarbonyl-4-oxo-3H-pyrimidin-2-yl)amino]butylamino]-4-oxo-3H-pyrimidine-5-carboxylate Structure

ethyl 2-[4-[(5-...

2H-1-Benzopyran-2-one,3-methyl- Structure

2H-1-Benzopyran...

bromhydrate de propanediylbisguanidine Structure

bromhydrate de ...

~43%

Phenol,2,2'-[1,3-propanediylbis[imino(5-methyl-2,4-pyrimidinediyl)]]bis- (9CI) Structure

Phenol,2,2'-[1,...

bromhydrate de butanediylbisguanidine Structure

bromhydrate de ...

2,4-Pentandione Structure

2,4-Pentandione

~21%

1,4-Butanediamine,N,N'-bis(4,6-dimethyl-2-pyrimidinyl)- (9CI) Structure

1,4-Butanediami...

bromhydrate de hexanediylbisguanidine Structure

bromhydrate de ...

Diethyl ethoxymethylenemalonate Structure

Diethyl ethoxym...

~40%

ethyl 2-[6-[(5-ethoxycarbonyl-4-oxo-3H-pyrimidin-2-yl)amino]hexylamino]-4-oxo-3H-pyrimidine-5-carboxylate Structure

ethyl 2-[6-[(5-...

1,6-Hexanediamine Structure

1,6-Hexanediamine

~%

ethyl 2-[6-[(5-ethoxycarbonyl-4-oxo-3H-pyrimidin-2-yl)amino]hexylamino]-4-oxo-3H-pyrimidine-5-carboxylate Structure

ethyl 2-[6-[(5-...

2H-1-Benzopyran-2-one,3-methyl- Structure

2H-1-Benzopyran...

bromhydrate de butanediylbisguanidine Structure

bromhydrate de ...

~63%

(6E)-6-[5-methyl-2-[4-[[(4E)-5-methyl-4-(6-oxo-1-cyclohexa-2,4-dienylidene)-3H-pyrimidin-2-yl]amino]butylamino]-3H-pyrimidin-4-ylidene]cyclohexa-2,4-dien-1-one Structure

(6E)-6-[5-methy...

2H-1-Benzopyran-2-one,3-methyl- Structure

2H-1-Benzopyran...

bromhydrate de hexanediylbisguanidine Structure

bromhydrate de ...

~77%

Phenol,2,2'-[1,6-hexanediylbis[imino(5-methyl-2,4-pyrimidinediyl)]]bis- (9CI) Structure

Phenol,2,2'-[1,...

1,6-Hexanediamine Structure

1,6-Hexanediamine

~%

Phenol,2,2'-[1,6-hexanediylbis[imino(5-methyl-2,4-pyrimidinediyl)]]bis- (9CI) Structure

Phenol,2,2'-[1,...

4,4-Dimethoxy-2-butanone Structure

4,4-Dimethoxy-2...

bromhydrate de hexanediylbisguanidine Structure

bromhydrate de ...

~40%

1,6-Hexanediamine,N,N'-bis(4-methyl-2-pyrimidinyl)- (9CI) Structure

1,6-Hexanediami...

1,6-Hexanediamine Structure

1,6-Hexanediamine

~%

1,6-Hexanediamine,N,N'-bis(4-methyl-2-pyrimidinyl)- (9CI) Structure

1,6-Hexanediami...

2-Chloro-4-methylpyrimidine Structure

2-Chloro-4-meth...

1,6-Hexanediamine Structure

1,6-Hexanediamine

~16%

1,6-Hexanediamine,N,N'-bis(4-methyl-2-pyrimidinyl)- (9CI) Structure

1,6-Hexanediami...

bromhydrate de propanediylbisguanidine Structure

bromhydrate de ...

2,4-Pentandione Structure

2,4-Pentandione

~76%

N,N-bis(4,6-dimethylpyrimidin-2-yl)propane-1,3-diamine Structure

N,N-bis(4,6-dim...