Organic & Biomolecular Chemistry 2009-11-07

Efficient method for the synthesis of functionalized pyrazoles by catalyst-free one-pot tandem reaction of nitroalkenes with ethyl diazoacetate.

Jian-Wu Xie, Zheng Wang, Wei-Jun Yang, Li-Chun Kong, Dong-Cheng Xu

Index: Org. Biomol. Chem. 7(21) , 4352-4, (2009)

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Abstract

The one-pot synthesis of multisubstituted pyrazole derivatives was achieved via catalyst-free 1,3-dipolar cycloaddition of ethyl diazoacetate and nitroalkenes as the key step and elimination of the leaving group (NO(2) or Br) followed by intramolecular proton transfer with satisfactory yields.