EDA

Modify Date: 2025-08-22 10:13:08

EDA Structure
EDA structure
 Common Name EDA
CAS Number 623-73-4 Molecular Weight 114.103
Density 1.085 g/mL at 25 °C(lit.) Boiling Point 140-141 °C720 mm Hg(lit.)
Molecular Formula C4H6N2O2 Melting Point −22 °C(lit.)
MSDS Chinese USA Flash Point 115 °F
Symbol GHS02 GHS07 GHS08
GHS02, GHS07, GHS08		 Signal Word Warning

 Use of EDA


Diazoacetic ester is also known as Ethyl Diazoacetate. Ethyl Diazoacetate is used in the synthesis of Arteludovicinolide A as well as pyrimidoazepine analogs as seritonin 5-HT2A/C receptor ligands for treatment of obesity. This compound contains solvent for added stability.

 Names

Name Ethyl diazoacetate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.085 g/mL at 25 °C(lit.)
Boiling Point 140-141 °C720 mm Hg(lit.)
Melting Point −22 °C(lit.)
Molecular Formula C4H6N2O2
Molecular Weight 114.103
Flash Point 115 °F
Exact Mass 114.042931
PSA 63.69000
LogP -0.57
Index of Refraction n20/D 1.46(lit.)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AG5775000
CHEMICAL NAME :
Acetic acid, diazo-, ethyl ester
CAS REGISTRY NUMBER :
623-73-4
LAST UPDATED :
199106
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C4-H6-N2-O2
MOLECULAR WEIGHT :
114.12
WISWESSER LINE NOTATION :
NNU1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XENOBH Xenobiotica. (Taylor & Francis Ltd., 4 John St., London WC1N 2ET, UK) V.1- 1971- Volume(issue)/page/year: 3,271,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 135,219,1970 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2025 mg/kg/81W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
REFERENCE :
XENOBH Xenobiotica. (Taylor & Francis Ltd., 4 John St., London WC1N 2ET, UK) V.1- 1971- Volume(issue)/page/year: 3,271,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4167 mg/kg/48W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949- Volume(issue)/page/year: 55,117,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 mg/kg/30W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949- Volume(issue)/page/year: 55,117,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
75 mg/kg/30W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949- Volume(issue)/page/year: 55,117,1985
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1330 mg/kg/53W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
REFERENCE :
BTPGAZ Beitraege zur Pathologie. (Stuttgart, Fed. Rep. Ger.) V.141-161, 1970-77. For publisher information, see PARPDS. Volume(issue)/page/year: 146,33,1972
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2400 mg/kg/68W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year: 50,99,1963
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2850 mg/kg/57W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
REFERENCE :
XENOBH Xenobiotica. (Taylor & Francis Ltd., 4 John St., London WC1N 2ET, UK) V.1- 1971- Volume(issue)/page/year: 3,271,1973
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1000 mg/kg/40W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 135,219,1970
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2150 mg/kg/86W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
REFERENCE :
ADRCAC Annali Italiani di Dermatologia Clinica e Sperimentale. (Clinica Dermosifilopatica Universita degli Studi, Policlinica Monteluce, 06100 Perugia, Italy) V.16- 1962- Volume(issue)/page/year: 19,51,1965
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4300 mg/kg/86W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
REFERENCE :
ADRCAC Annali Italiani di Dermatologia Clinica e Sperimentale. (Clinica Dermosifilopatica Universita degli Studi, Policlinica Monteluce, 06100 Perugia, Italy) V.16- 1962- Volume(issue)/page/year: 19,51,1965
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 3,785,1982

 Safety Information

Symbol GHS02 GHS07 GHS08
GHS02, GHS07, GHS08
Signal Word Warning
Hazard Statements H226-H242-H302-H351
Precautionary Statements P281
Hazard Codes Xn:Harmful;
Risk Phrases R5;R10;R22;R40
Safety Phrases 36/37
RIDADR UN 1993 3/PG 3
WGK Germany 3
RTECS AG5775000
Packaging Group III
Hazard Class 3.2
HS Code 2927000090

 Synthetic Route

 Customs

HS Code 2927000090
Summary 2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles29

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Silver-catalyzed vinylogous fluorination of vinyl diazoacetates.

Org. Lett. 15(24) , 6152-4, (2013)

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 Synonyms

Ethyl Diazoethanoate
EINECS 210-810-8
Diazoacetic acid ethyl ester
(E)-2-diazonio-1-ethoxyethenolate
EDA
MFCD00001989
Diazoacetic Ester
Acetic acid, 2-diazo-, ethyl ester
Ethyl diazoacetate
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