Tetrahedron

The synthesis of (±)-aminoglutethimide via vicarious nucleophilic aromatic substitution of hydrogen

SM Bushell, JP Crump, NJ Lawrence, G Pineau

Index: Bushell, Simon M.; Crump, J. Paul; Lawrence, Nicholas J.; Pineau, Guillaume Tetrahedron, 1998 , vol. 54, # 10 p. 2269 - 2274

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Citation Number: 8

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The synthesis of aminoglutethimide via a one-pot coupling of nitrobenzene, ethyl 2-chlorobutyrate and 3-bromopropionitrile has been achieved via a process involving sequential vicarious nucleophilic aromatic substitution and alkylation. ... The synthesis of aminoglutethimide from ...

~65%

~59%

~56%

~53%

~61%

Arzneiformen

[Hamacher; Bormann Archiv der Pharmazie, 1981 , vol. 314, # 3 p. 257 - 267]

Steroidal esters of the aromatic nitrogen mustard 2-[4-N, N-...

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