Organic letters

A Useful Pd-Catalyzed Negishi Coupling Approach to Benzylic Sulfonamide Derivatives

G Zhou, P Ting, R Aslanian, JJ Piwinski

Index: Zhou, Gang; Ting, Pauline; Aslanian, Robert; Piwinski, John J. Organic Letters, 2008 , vol. 10, # 12 p. 2517 - 2520

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Citation Number: 25

Abstract

A mild catalytic system to access diversely functionalized benzylic sulfonamides has been developed. Palladium-catalyzed α-arylation by Negishi cross-coupling of sulfonamide- stabilized anions and a wide range of aryl iodides, bromides, and triflates constitutes a practical strategy for the synthesis of various benzylic sulfonamides.