Tetrahedron

on the azetidin-2-one ring formation. A 1H NMR investigation.

A Bolognese, MV Diurno, O Mazzoni, F Giordano

Index: Bolognese, Adele; Diurno, M. Vittoria; Mazzoni, Orazio; Giordano, Federico Tetrahedron, 1991 , vol. 47, # 35 p. 7417 - 7428

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Citation Number: 20

Abstract

Azetidin-2-ones were prepared by addition of phenylacetic acid chloride to substituted benzal-anilines in DMF. The effect of temperature and substituents at the benzal-anilines on the reaction mechanism was investigated carrying out the reaction in DMF d7 in an NMR probe of a Bruker 400-MHz spectrometer at 25 and 60° C. Proton signals, arising from two kinds of intermediates a 2-phenyl-N-(α-chlorobenzyl)-acetanilide (6) and a nitrogen- ...