Synlett

Pd-catalyzed synthesis of functionalized arylketones from boronic acids and carboxylic acids activated in situ with dimethyl dicarbonate

…, L Winkel, A Doehring, K Ghosh, J Paetzold

Index: Goossen, Lukas J.; Winkel, Lars; Doehring, Arno; Ghosh, Keya; Paetzold, Jens Synlett, 2002 , # 8 p. 1237 - 1240

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Citation Number: 32

Abstract

Abstract Highly efficient catalyst systems were developed that allow the palladium-catalyzed cross-coupling of arylboronic acids with carboxylic acids activated in situ with dimethyl dicarbonate at room temperature. As byproducts, only methanol, CO 2, and boric acid are formed, making the isolation of the products particularly easy. Thus, many functionalized ketones are conveniently accessible from boronic and carboxylic acids in the presence of ...