European Journal of Medicinal Chemistry 2010-01-01

Design, synthesis, andin vitroantitumor evaluation of novel diaryl ureas derivatives

Min Sun, Xiaoqing Wu, Junqing Chen, Jin Cai, Meng Cao, Min Ji, Min Sun, Xiaoqing Wu, Junqing Chen, Jin Cai, Meng Cao, Min Ji

Index: Eur. J. Med. Chem. 45(6) , 2299-306, (2010)

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Abstract

Two series of novel diaryl ureas have been designed and synthesized, with their in vitro antitumor effect screened on human non-small cell lung cancer (NSCLC) cell line A549 and human breast cancer cell line MDA-MB-231. Some target compounds demonstrated significant inhibitory activities against both cell lines. Compared to contrast drug Sorafenib, 1b, 1d, 1f, 1i were found to demonstrate more potent antitumor activities. The structures of all the newly synthesized compounds were determined by 1H, 13C NMR, MS, IR and elementary analysis.