Sulfonamide Synthesis via Oxyma??O??sulfonates–Compatibility to Acid Sensitive Groups and Solid??Phase Peptide Synthesis

…, S Rana, KC Nadimpally, B Mandal

Index: Palakurthy, Nani Babu; Dev, Dharm; Rana, Shubhasmin; Nadimpally, Krishna Chaitanya; Mandal, Bhubaneswar European Journal of Organic Chemistry, 2013 , # 13 p. 2627 - 2633

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Abstract

Abstract A milder and more efficient procedure for the synthesis of sulfonamides by activating sulfonic acid groups as the corresponding sulfonate esters of ethyl 2-cyano-2- (hydroxyimino) acetate (Oxyma) is reported. This method is greener than all other existing protocols for the purpose. Other important advantages lie in (a) its applicability to less nucleophilic anilines under ambient and milder conditions and (b) its compatibility with ...