BTS

Modify Date: 2024-01-02 10:58:08

BTS Structure
BTS structure
Common Name BTS
CAS Number 1576-37-0 Molecular Weight 261.33900
Density 1.204 g/cm3 Boiling Point 419.1ºC at 760 mmHg
Molecular Formula C14H15NO2S Melting Point 115 °C
MSDS N/A Flash Point 207.3ºC

 Use of BTS


BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 ~ 5 μM) and reversibly blocks the gliding motility. IC50 value: 5 uMTarget: Ca2+-stimulated myosin S1 ATPaseBTS also weakens myosin’s interaction with F-actin. BTS is much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.

 Names

Name N-benzyl-4-methylbenzenesulfonamide
Synonym More Synonyms

 BTS Biological Activity

Description BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 ~ 5 μM) and reversibly blocks the gliding motility. IC50 value: 5 uMTarget: Ca2+-stimulated myosin S1 ATPaseBTS also weakens myosin’s interaction with F-actin. BTS is much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.
Related Catalog
References

[1]. Cheung A, et al. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol. 2002 Jan;4(1):83-8.

 Chemical & Physical Properties

Density 1.204 g/cm3
Boiling Point 419.1ºC at 760 mmHg
Melting Point 115 °C
Molecular Formula C14H15NO2S
Molecular Weight 261.33900
Flash Point 207.3ºC
Exact Mass 261.08200
PSA 54.55000
LogP 3.94520
Vapour Pressure 3.12E-07mmHg at 25°C
Index of Refraction 1.589
Storage condition Desiccate at RT

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XT5490000
CHEMICAL NAME :
p-Toluenesulfonamide, N-benzyl-
CAS REGISTRY NUMBER :
1576-37-0
BEILSTEIN REFERENCE NO. :
2217277
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H15-N-O2-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,41,1953

 Safety Information

RTECS XT5490000
HS Code 2935009090

 Synthetic Route

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Synonyms

p-Toluenesulfonamide,N-benzyl
N-Tosylbenzylamine
N-Benzyl-4-methylbenzenesulfonamide
N-Benzyl-p-toluenesulfonamide
N-Benzyl-p-toluenesulphonamide
N-Benzyl-4-methyl-benzenesulfonamide
MFCD00159328
BTS
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