Drug metabolism letters 2007-01-01

Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam.

M Olivera, C Martínez, G Gervasini, J A Carrillo, S Ramos, J Benítez, E García-Martin, J A G Agúndez

Index: Drug Metab. Lett. 1(1) , 3-5, (2007)

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Abstract

We investigated the role of NAT2 on clonazepam acetylation, using transiently expressed human NAT2 alleles. The NAT25*B and the NAT2*6A variant alleles cause a 20 and 22-fold reduction in the Vmax, respectively. We conclude that NAT2 is responsible for 7-aminoclonazepam acetylation and that NAT2 gene polymorphisms impair such metabolic pathway.