7-Aminoclonazepam(CRM)
7-Aminoclonazepam(CRM) structure
|
Common Name | 7-Aminoclonazepam(CRM) | ||
|---|---|---|---|---|
| CAS Number | 4959-17-5 | Molecular Weight | 285.728 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 533.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C15H12ClN3O | Melting Point | 226-228ºC | |
| MSDS | N/A | Flash Point | 276.5±32.9 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
|
Extraction and analysis of clonazepam and 7-aminoclonazepam in whole blood using a dual internal standard methodology.
Forensic Sci. Int. 166(2-3) , 209-17, (2007) In this paper, a simple and robust method for the determination of clonazepam and its primary metabolite (7-aminoclonazepam) in whole blood is described. Clonazepam (klonopin) is a popular prescription drug that has been implicated in the field of drug facili... |
|
|
A highly sensitive method for the determination of 7-aminonitrazepam, a metabolite of nitrazepam, in human urine using high-performance electrospray liquid chromatography tandem mass spectrometry.
Biomed. Chromatogr. 23(7) , 740-4, (2009) A highly sensitive method has been developed for the determination of urinary 7-aminonitrazepam (7-ANZP), the major metabolite of nitrazepam, using high-performance electrospray liquid chromatography tandem mass spectrometry. The samples were prepared for ana... |
|
|
Simultaneous determination and quantification of 12 benzodiazepines in serum or whole blood using UPLC/MS/MS.
Methods Mol. Biol. 603 , 107-19, (2010) The benzodiazepines are a large, commonly prescribed family of psychoactive drugs. We describe a method permitting the simultaneous detection and quantification of 12 benzodiazepines in serum using ultra-performance liquid chromatography (UPLC) coupled with t... |
|
|
LC-MS/MS analysis of 13 benzodiazepines and metabolites in urine, serum, plasma, and meconium.
Methods Mol. Biol. 603 , 89-105, (2010) We describe a single method for the detection and quantitation of 13 commonly prescribed benzodiazepines and metabolites: alpha-hydroxyalprazolam, alpha-hydroxyethylflurazepam, alpha-hydroxytriazolam, alprazolam, desalkylflurazepam, diazepam, lorazepam, midaz... |
|
|
Prolonged excretion of 7-aminoclonazepam in urine after repeated ingestion of clonazepam: a case report.
Forensic Sci. Int. 222(1-3) , e33-5, (2012) Urinary analyses of the metabolite 7-aminoclonazepam (7-AC) can be helpful in monitoring drug abuse and in the context of suspected drug-facilitated sexual assaults (DFSA). Only two studies have reported detection times of 7-AC in urine after a single dose of... |
|
|
Quantitation of clonazepam and its 7-amino and 7-acetamido metabolites in plasma by high-performance liquid chromatography.
J. Chromatogr. A. 306 , 241-8, (1984) A high-performance liquid chromatographic method is reported for the determination of clonazepam and its metabolites 7-amino- and 7-acetamidoclonazepam. Extraction from buffered plasma is carried out at pH 9.5 with hexane-ethyl acetate (7:3) for clonazepam an... |
|
|
Polymorphic acetylation of 7-amino-clonazepam in human liver cytosol.
Pediatr. Pharmacol. (New York.) 4(3) , 155-9, (1984) The N-acetylation of the reduced metabolite of clonazepam 7-amino-clonazepam was studied in cytosolic preparation from human fetal and adult livers. The metabolite formed 7-acetamido-clonazepam was measured with high performance liquid chromatography. A bimod... |
|
|
Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam.
Drug Metab. Lett. 1(1) , 3-5, (2007) We investigated the role of NAT2 on clonazepam acetylation, using transiently expressed human NAT2 alleles. The NAT25*B and the NAT2*6A variant alleles cause a 20 and 22-fold reduction in the Vmax, respectively. We conclude that NAT2 is responsible for 7-amin... |
|
|
Blood concentrations of clonazepam and 7-aminoclonazepam in forensic cases in Denmark for the period 2002–2007
Forensic Sci. Int. 184(1-3) , 74-9, (2009) The benzodiazepine clonazepam is a prescription drug used to treat epilepsy and anxiety. In addition, it is frequently used to treat drug addicts and is itself a popular drug of abuse. In this study, we report the incidence and blood concentrations of clonaze... |
|
|
Ultrasensitive immunoassay of 7-aminoclonazepam in human urine based on CdTe nanoparticle bioconjugations by fabricated microfluidic chip
Biosens. Bioelectron. 24(7) , 2051-6, (2009) The present paper described a rapid and ultrasensitive detection method using a microfluidic chip for analyzing 7-aminoclonazepam (7-ACZP) residues in human urine. A microfluidic chip-based immunoassay with laser-induced fluorescence (LIF) detection based on ... |