Antimicrobial Agents and Chemotherapy 2006-08-01

In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs.

Timothy M E Davis, Juliana Hamzah, Kenneth F Ilett, Harin A Karunajeewa, John C Reeder, Kevin T Batty, Sara Hackett, P Hugh R Barrett

Index: Antimicrob. Agents Chemother. 50 , 2883-2885, (2006)

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Abstract

In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.