Facile and regioselective dealkylation of alkyl aryl ethers using niobium (V) pentachloride

Y Sudo, S Arai, A Nishida

Index: Sudo, Yukinori; Arai, Shigeru; Nishida, Atsushi European Journal of Organic Chemistry, 2006 , # 3 p. 752 - 758

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Citation Number: 21

Abstract

Abstract A simple and facile method for the cleavage of carbon–oxygen bonds promoted by niobium pentachloride (V) is described. Excellent yields and regioselectivities were observed with various alkyl aryl ethers to give the phenols. NMR studies revealed the formation of monoaryloxy niobium salt (V), and a neighboring-group effect may play a significant role in the regioselectivity.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 ...