Tetrahedron

Practical one-pot preparation of ketones from aryl and alkyl bromides with aldehydes and DIH via Grignard reagents

S Dohi, K Moriyama, H Togo

Index: Dohi, Souya; Moriyama, Katsuhiko; Togo, Hideo Tetrahedron, 2012 , vol. 68, # 32 p. 6557 - 6564

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Citation Number: 12

Abstract

Various diaryl ketones, alkyl aryl ketones, and dialkyl ketones were efficiently prepared in good yields by the reactions of the Grignard reagents derived from aryl or alkyl bromides, followed by the reactions with aromatic or aliphatic aldehydes and the subsequent treatment with 1, 3-diiodo-5, 5-dimethylhydantoin and K2CO3, in a one-pot method. The same treatment of aromatic bromides bearing electron-withdrawing groups, such as ester, nitrile, ...