Ring contraction of a 5??acetylpyrimidine into pyrazoles by the action of substituted hydrazines in acidic medium

G Menichi, M Boutar, B Kokel, K Takagi…

Index: Menichi; Boutar; Kokel; et al. Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 1 p. 275 - 279

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Citation Number: 15

Abstract

Abstract We have found previously that two 5-acetyl-4-methylpyrimidines could be transformed by aminoguanidine hydrochloride into 4-acetyl-1-amidino-3-methylpyrazolyl amidinohydrazone dihydrochloride. This reaction beside the fact that it led to a molecule closely related to the antitumor drug MGBG pointed out to a new possibility of ring contraction of pyrimidines into pyrazoles. We attempted therefore to study the possibility of ...